I recently upgraded to Windows Vista x64 on a Dell M6300 with 4GB of RAM. So far I've been blown away by the snappy performance of the system itself and, in particular, all of the Autodesk software that I've run on it so far (Civil 3D 2009, AutoCAD 2009, Map 2009).
I've heard all of the horror stories of Vista and, yes, I've seen the Apple commercials, but since I purchased the system new as a 64 bit workstation, Dell naturally configured it with hardware which is all supported by Vista x64. The only peripheral that I had to worry about was my old Lexmark P4350 printer, which luckily, Lexmark provides a driver for.
I should also point out that I've turned off all of the eye candy which I just don't need. Even in XP, I've always been one to turn off window animations, cursor shadows, smooth scrolling, start menu animation, and all of the rest of the fluff that just doesn't add to productivity. With Vista, I've decided to configure it about the same. After just a few days, things are going extremely well.
It's still way to early to tell, but I think I'm going to be very happy with Vista x64 and this system in general.
I'll post some benchmarks as soon as I can.
(For the Linux trolls, I should also point out that this system is for business apps that Linux simply won't run. I like linux. I get it. I know that it's good and I have ubuntu on my old old laptop. I've used it off an on, when I had a specific use for it, since about 1993 when I used slackware on a '386. So please don't try to convince me that any Linux flavor is superior to Vista. For the apps I run, it's very apparent that Vista x64 was a wise choice).